A Case of Infantile Kyrle-Flegel Disease in a 6-Year-Old Yemeni Girl.

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US National Library of Medicine National Institutes of Health Search database Search term PubMed Search Advanced Help Try the new PubMed! Result Filters Format: Abstract Format Summary Summary (text) Abstract Abstract (text) MEDLINE XML PMID List Apply Send to Choose Destination File Clipboard Collections E-mail Order My Bibliography Citation manager Format

Abstract (text) Create File 1 selected item: 26933407 Format Abstract MeSH and Other Data E-mail Subject 1 selected item: 26933407 - PubMed Additional text E-mail Didn't get the message? Find out why... Add to Clipboard Add to Collections Order articles Fetching bibliography... My Bibliography Add to Bibliography Generate a file for use with external citation management software. Create File Case Rep Dermatol. 2016 Jan 20;8(1):5-9. doi: 10.1159/000443824. eCollection 2016 Jan-Apr. A Case of Infantile Kyrle-Flegel Disease in a 6Year-Old Yemeni Girl. Alshami MA1, Mohana MJ1. Author information 1 Dermatology Department, University Hospital, Sana'a University, Sana'a, Yemen. Abstract Kyrle disease (KD) and Flegel disease (FD) are rare variants of primary perforating dermatoses, characterized by transepidermal elimination of abnormal endogenous materials. We describe a 6-year-old Yemeni girl with a 2-year history of generalized asymptomatic, small, reddish-brown keratotic papules with a lenticular central keratotic plug. Although these features are synonymous with FD, the histology of a punch biopsy was consistent with KD. The patient was otherwise healthy, and no family members had a history of similar diseases. The patient was diagnosed with KD-FD, owing to the manifestation of features associated with both diseases. KEYWORDS: Flegel disease; Keratotic plug; Kyrle disease; Nodule; Papule PMID:

26933407 PMCID: PMC4772611 DOI: 10.1159/000443824 Free PMC Article Share Images from this publication.See all images (1)Free text Fig. 1 a Lateral view of the right leg, showing multiple small red-brown papules 13 mm in size with a central keratotic plug. b Close-up view of the area displayed in a, showing many typical lesions at different stages of development. A hair can be seen protruding out of some of the follicular (F) lesions but not out of the parafollicular (PF) lesions. c Histology of the lesion, showing the keratinous plug (1) filling the epidermal invagination (EI). Parakeratosis (2) and basophilic debris (3) can be seen within the plug. There is a dense inflammatory infiltrate (4) in the upper dermis. A Case of Infantile Kyrle-Flegel Disease in a 6-Year-Old Yemeni Girl Case Rep Dermatol. 2016 Jan-Apr;8(1):5-9. Publication type Publication type Case Reports LinkOut - more resources Full Text Sources S. Karger AG, Basel, Switzerland Europe PubMed Central PubMed Central Supplemental Content Full text links You are here: NCBI > Literature > PubMed Support Center Simple NCBI Directory Getting Started NCBI Education NCBI Help Manual NCBI Handbook Training & Tutorials Submit Data Resources

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