A2 Biology - Get Revising

A2 Biology - Get Revising

A2 BIOLOGY SKELETAL MUSCLE Module 4 Section 4.3 Coordination and Control: Animals Specification Skeletal muscle

The tissue most commonly thought of as muscle is skeletal muscle

Skeletal muscles cover your skeleton, giving your body its shape. Attached to your skeleton by tendons or directly to bone Under voluntary control (you consciously control what they do)

All body movement is caused by skeletal muscle contraction Skeletal muscle Important for holding your bones in the correct position

Prevents your joints from dislocating Some skeletal muscles in your face are directly attached to your skin and contraction of one of these muscles changes your facial expression

Generates heat as a by-product of muscle activity This heat is vital for maintaining your normal body temperature Muscles

At a very basic level each muscle fibre is made up of smaller fibres called myofibrils These contain even smaller structures

called actin and myosin filaments. These filaments slide in and out between each other to form a muscle contraction, hence called the sliding filament theory! Muscle external structure Muscle external structure

The sarcomere The diagram above shows part a myofibril called a sarcomere. This is the smallest unit of skeletal muscle that can contract. Sarcomeres repeat themselves over and over along the length of the myofibril. Structures involved

Myofibril: A cylindrical organelle running the length of the muscle fibre,

containing Actin and Myosin filaments. Sarcomere: The functional unit of the Myofibril, divided into I, A and H bands. Actin: A thin, contractile protein filament, containing 'active' or 'binding' sites. Myosin: A thick, contractile protein filament, with protrusions known as Myosin Heads.

Example diagrams Example diagrams Example diagrams Example diagrams

Muscle contraction A series of events has to occur for muscle contraction to occur Described here is more detail than you

require, but it good to get an appreciation of the scale of this process How muscles contract 1) A nervous impulse arrives at the neuromuscular junction, which causes a release of a chemical

called Acetylcholine. The presence of Acetylcholine causes the depolarisation of the motor end plate which travels throughout the muscle by the transverse tubules, causing Calcium (Ca2+) to be released from

2) In the presence of high concentrations of Ca+, the Ca+ binds to Troponin, changing its shape and so moving Tropomyosin from the active site of the Actin. The Myosin filaments can now attach to the Actin, forming a cross-bridge.

3) The breakdown of ATP releases energy which enables the Myosin to pull the Actin filaments inwards and so shortening the muscle. This occurs along the entire length of every myofibril in the muscle cell.

4) The Myosin detaches from the Actin and the cross-bridge is broken when an ATP molecule binds to the Myosin head. When the ATP is then broken down the Myosin head can again attach to an Actin binding site further along the Actin filament and repeat the 'power stroke'. This repeated pulling of the Actin over the myosin is often known as the

ratchet mechanism. 5) This process of muscular contraction can last for as long as there is adequate ATP and Ca2+ stores. Once the impulse stops the Ca2+ is pumped back to the Sarcoplasmic Reticulum and the Actin

returns to its resting position causing the muscle to lengthen and relax. The sliding filament theory Summary of events 1. 2.

3. 4. 5. The influx of calcium from the sarcoplasmic reticulum triggers the exposure of binding sites on action

Myosin binds to the actin The power stroke of the cross bridge occurs, which causes the sliding of the thin filaments ATP binds to the cross bridge, resulting in the cross bridge disconnecting from the actin The ATP is hydrolysed, leading to the repositioning of the cross bridge Relaxed muscle

Looking at the diagram above again, shows a stretched muscle where the I - bands and the H - zone is elongated due to reduced overlapping of the myosin and actin filaments. There would be reduced muscle strength because few cross bridges can form between the actin and myosin.

Partially contracted muscle The diagram above shows a partially contracted muscle where there is more overlapping of the myosin and actin with lots of potential for cross bridges to form. The I - bands and H - zone are

shortened. Contracted muscle The diagram above shows a fully contracted muscle with lots of overlap between the actin and myosin. Because the thin actin filaments have overlapped

there is a reduced potential for cross bridges to form again. EM comparison of muscle states

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