Altered Steroid Responsiveness in Severe Asthma

Altered Steroid Responsiveness in Severe Asthma

General Faculty Meeting Monica Kraft, M.D. The Robert and Irene Flinn Professor of Medicine Chair, Department of Medicine, University of Arizona College of Medicine Tucson Deputy Director, Asthma and Airway Disease Research Center, University of Arizona Health Sciences Tuesday, March 19, 2019 Agenda 5:30-7:00 p.m. 1. Introductions Monica Kraft, MD, Chair, UA Department of Medicine 2. Introduction & Q&A Chad Whelan, MD, CEO, Banner University Medicine 3. P&T Updates Terri Buchanan, Personnel Coordinator, UA Department of Medicine 4. Physician Training for Potential Suport How to Work, Partner with Development Office to Identify, Cultivate Relationships with Donors Manon OConnor, Acting Assoc. Vice President and Chief Development Officer, UAHS, and Sr. Development Director, UA College of Medicine Tucson 5. Accolades & Awards Monica Kraft, MD, Chair, UA Department of Medicine 6. Clinical Affairs Update Tammy Ojo, MD, Associate Chair, Clinical Affairs, UA Department of Medicine

7. Educational Update Dr. Amy Sussman, Associate Chair, Education, UA Department of Medicine New Hires November 2018 - present Rocio Zapata-Bustos, PhD Mark Schomogyi, MD Oleh Haluszka, MD Jamilah Shubeilat, MD Research Assistant Professor | Endocrinology Clinical Assistant Professor | Infectious Diseases Clinical Professor | Gastroenterology & Hepatology Clinical Assistant Professor | Infectious Diseases Anne Marie Canelas, MD Bobu Mohan, MD Clinical Assistant Professor | GGP Bulbul Cibei, MD

Clinical Assistant Professor | Inpatient Medicine Clinical Assistant Professor | GGP General Internal Medicine Ritika Ohri, MD Julie B. Jernberg, MD Kosuke Kato, PhD Clinical Assistant Professor | GGP Malvika Varma, MD Clinical Assistant Professor | GGP GIM Clinical Assistant Professor | Nephrology Research Assistant Professor | Pulmonary, Allergy, Critical Care & Sleep Medicine Accolades & Awards November 2018 March 2019 Education National/Global Recognition As editor-in-chief of Circulation: Heart Failure, Dr. Nancy Sweitzer joins 28 other journal editors

and 22 publications globally in publishing an editorial Medical Misinformation: Vet the Message! in January as part of an effort to On top of an earlier gift of $5 million, Dr. stop dissemination of misleading medical Andrew Weil, founding director of the UA Center on Integrative Medicine, now renamed information on social media.. in his honor, commits another $15 million. It establishes the Andrew Weil Endowed Chair Dr. Rachna Shroff speaks at the in Integrative Medicine, Andrew Weil 3rd Asia-Pacific CholangiocarcinoEndowed Chair for Research in Intema Conference in Taipei, Taiwan, grative Medicine (which will go to Dr. for which she served on the Esther Sternberg) and Andrew Weil Scientific Committee. Her topic: Parallel MulEndowed Program Fund for Integrative tidiscipline Approach for Locally Advanced Medicine. Pictured above at the HSIB event Diseases Down-Staging. She and Dr. to announce his gift are UA President Dr. Hani Babiker also were presenters at Robert Robbins, Dr. Weil, UAHS Sr. V.P. the GI Cancers Symposium in San FranDr. Michael Dake and the centers executive cisco, and she presented at the Spring Series director Dr. Victoria Maizes. of UA CBIO Seminars as well. Education National/Global Recognition Cardiologist and director of the UA Arizona Center

for Advanced Biomedical Innovation, Dr. Marvin Slepian co-chairs an international forum March 7-8 on Virtual Reality & Healthcare from UA Student Union Memorial Center. UA Center on Aging research and education director, Dr. Linda Phillips authors opeds for Arizona Daily Star and DCpolitical-newspaper The Hill on image of the elderly and impact of higher drug prices., a virtual community for women in medicine, posts blog by Dr. Indu Partha on Why Internal Medicine?where she discusses importance of internal medicine education in inpatient settings for residents and medical students. Co-chief of Division of Genetics, Genomics and Precision Medicine, Dr. Deb Meyers chosen to be a Cardiologist Dr. Joseph Alpert speaks council member for the at UC San Diego/Scripps Memorial HosCollegium Internationale pital, La Jolla, on The Universal DefiniAllergologicum, which Dr. tion of MI: Consensus & Controversy and the Donata Vercelli will lead as University of Rochester on What I Learned first female secretary general from 40+ Years of Clinical Medicine -elect. Education UA/State Recognition

Dr. John Galgiani coordinates with Arizona Department of Health Services and the Maricopa County Department of Public Health to launch a Valley fever billboard awareness campaign in Phoenix in March funded by UA Foundation. Aware- A dozen winners are announced in last falls statewide Valley Fever Among 18 DOM faculty and staff to be recognized at UA Years of Service Awards (for milestones of 10, 15, and 20 years, etc., as UA employees) are: Drs. Clara Curiel, Emad Elquza, Steve Knoper, Linda Snyder, Amy Sussman and Eugene Trowers. In addition, Drs. Rick Ahmann, Faiz Anwer, Steve Goldschmid, David Johnson and Victoria Sanguinetti also are to be honored at the UA Retiree Dinner. Dr. Eugene Trowers lauds South Campus Internal Medicine Residents for taking 1st and 2nd prizes in four of six contests at the ness Youth Poster Art ConACP Arizona

test sponsored by the ADHS in Chapter Sciencoordination with the UA Valley tific Meeting. Fever Center for Excellence ranging in age from 5 to 17. Education Community Presence A January article in Tucson Lifestyle, Theres More to the Snore, takes UA sleep medicine expert and Pulmonary Chief Dr. Sai Parthasarathys pulse on the latest treatment options for sleep apnea. Others winning magazine ink around New Year include: Dr. Peter Ott (Tucson Lifestyle); Dr. Vivian Shi (Experience Life!); and Dr. Esther Sternberg (New York Magazine). Hospitalist Dr. Bujji Ainapurapu among parents at packed-house 4th A Pathway to Success High School Health Career Fair at Banner UMC South. Inspired by internal medicine residents, it drew 135: 81 students, 46 parents and guests, and 8 teachers Nine DOM physicians among 17 instructors at THE TUCSON CONFERENCE, an 8.5-CME event Feb. 2 at Tucson Marriott University Park: Drs. Edwin Aquino, Julie Bauman, Tara Carr, Jason

DuPont, Steve Knoper, Deb Meyers, Merri Pendergrass, James Sligh, and Nancy Sweitzer. Organizing committee includes Drs. Monica Kraft and Robert Segal. Four instructors represent TMC, NW Medical Center, El Rio Health and Arizona Oncology. Dr. Monica Kraft a finalist as Healthcare Champion at Inside Tucson Business Women of Influence Awards. Cardiac electrophysiology director, Dr. Matthew Hutchinson spoke at the UA/Banner Doc Talk lecture March 5 on Heart Health. Education Community Presence Infectious Diseases Dr. John Galgiani is interviewed for Tucson Lifestyle article on Valley fever, Digging for a Diagnosis, that highlights efforts to train primary care physicians statewide on new clinical guidance protocols developed in collaboration with Banner Health. Dr. Sachin Chaudhary co-chairs complimentary 3.5-CME event, Empowering the IPF Patient, Dec. 3, at Aloft Tucson University with National Jewish Healths Dr. Gregory Cosgrove, who also is CMO for the Pulmonary Fibrosis Foundation. Dr. Ken Ramos gives keynote address at 2019 Living Healthy With Arthritis Annual Conference on The Power of Precision Medicine. Shortly after, he announces hell move to Texas A&M (Houston) as vice chancellor of health services. Drs. Ruslav Rafikov and Evgeny

Zemskov, participate in On Our Own Time Art Exhibit hosted by UA and National Arts Program in BSRL lobby. Works by Dr. Rafikov and Dr. Zemskovs daughter, Varvara Zemskova, win recognition. UA Divisions of Nephrology, Urology host 2.0-CME Dinner Lecture on Dec. 15 on A Multidisciplinary Approach to Managing Kidney Stones at the Westward Look Resort, with NYU Langone Healths Dr. David Goldfarb as the keynote speaker. Twenty DOM physicians on preview list for Top Doctors to appear in Tucson Lifestyle June 2019 issue, a quarter of those from UA College of Medicine Tucson/BUMG Tucson to make the list. Clinical National/Global Recognition UA pulmonologists and rheumatologists work together to get UAHS research facilities and Banner UMC clinical facilities named a Scleroderma Research & Treatment Center an effort led by Drs. Sachin Chaudhary and Alicia Rodriguez-Pla. Benefits include greater patient referrals, clinical trials and research funding. UA TREAT Program Director Dr. Karen

Herbst wins R13 grant from the NIH/NHLBI to support a conference, Standard of Care for Lipedema in the United States in Baltimore in April. Its the first U.S. conference of its kind on adipose tissue disorders. After, shell give keynote address at Fat Disorders Resource Societys annual meeting, also in Baltimore. Banner UMC Tucson, Phoenix participating in expansion of national Early Access Program for Idiopathic Pulmonary Fibrosis genomic classifier, Envisia from Veracyte, under guidance of ILD Program Director Dr. Sachin Chaudhary. Clinical UA/State Activities UA President Dr. Robert C. Robbins presents the Mary Anne Fay Womens Heart Health Advocate of the Year Award to Dr. Nancy Sweitzer. Rheumatologist Dr. Dominick Sudano represents DOM on a Health Care Disparities Forum panel Feb. 18 to discuss, Putting the U in U of A! Health-care Disparities and How You Can Help. He focused on a Eli Lilly-funded collaboration with the Arizona Telemedicine Program and Indian Health Services to provide remote medical consultations for underserved Native Americans in rural areas. Dr. Khadijah Breathett gives third

and final lecture in UAHS African American Heritage Month lectures on Racial and Gender Disparities in Heart Failure. A 69-year-old woman with a congenital heart defect singles out Drs. Raj Janarhanan, Franz Rischard and Michael Seckeler for praise in a UA Sarver Heart Center Newsletter article on a procedure to repair the clinical issue made possible by using a 3D printer to model her heart. Clinical Community Presence Charles Katzenberg, MD, and Sarver Heart Series partners collaborating with El Rio Health to extend positive patient results from a study of 105 Heart Series participants able to lose weight, lower their blood pressure and improve lipid values. Only one of 105 participants had a hospitalization, necessary for the placement of a coronary stent. UA results were published in the American Journal of Medicine. Dr. Janet Funk reports in article on links of turmeric supplements with liver disease and warns patients to inform providers about all overthe-counter supplements theyre taking: Natural is not synonymous with safe.

UA Petersen HIV Clinics, a clinical care and outreach program overseen by the UA Division of Infectious Diseases at Banner UMC in Tucson, participates in local festivities for the 16th Annual National Latino AIDS Awareness Day (NLAAD) at the Abrams Public Health Center. In MedPage Today article, Dr. Khadijah Breathett calls blood pressure intervention in barbershops on behalf of African Americans as a landmark study (that) heralds the need to engage community members where they live. Research UA/State Activities Integrative Medicines Dr. Esther Sternberg was one of three keynote speakers at the College of Medicine - Tucsons Research Day 2019, which served as the inaugural event for the new Health Sciences Innovation Building. Her TED-style talk focused on: Measuring Health, Wellbeing and Performance Non-invasively: From Molecules to the Environment. yere, Dr. Daniel Combs, Dr. Jen Koevary, Dr. Julie Ledford, Dr. Yana

Roka-Moiia, Dr. Nancy Sweitzer, Dr. Khadijah Breathett, Anastasia Miramontes, Marisol Allen, Dr. Joanne Berghout, Marleen Ibarra, Sanga Shir and Maxwell Li. And for Research Day 2019s Taking part in the Data Blitzes portion of grand finale, the Shark Tank competition, the department Research Day 2019 from the UA Department was represented by researchof Medicine or research-affiliated centers were ers Dr. Louise Hecker, Dr. (in order of appearance): Dr. Craig Weinkauf, Marvin Slepian and a twoMicah Donovan, Dr. Fariba Donovan, person team of Dr. Monica Kraft and Julie James Fusaro, Dr. Daniel Powell, Dr. Lisa Ledford that won the $10,000 prize. Shubitz, Dr. Nancy Casanova, Ike Chin- Research UA/State Activities Third annual P.I. Poster Night showcases key research and investigators across the n Department of Medicine, with 40 posters on display Jan. 9. See Research Academic Half Day poster contest April 18 for Tucson Campus internal medicine residents and some fellows research as well.

The UA Department of Medicine launches an exclusive Statistical Support Service for research of faculty, fellows and residents with the UAHS/BIO5 StatLab. New UA sleep medicine specialists Drs. Salma and Imran Patel among interdisciplinary team members featured in new website for UAHS Center for Sleep and Circadian Sciences. A startup firm led by Dr. Louise Hecker, Fibronox licenses UA-developed small molecule inhibitor for therapy to treat lifethreatening scarring diseases such as idiopathic pulmonary fibrosis. Cardiologys Dr. Jil Tardiff gives keynote address at Inspiring Women in STEM event hosted by UA BIO5 Institute in month-long showcase of work it does to promote research, innovation, collaboration at university. Research UA/State Activities UA cardiovascular research team with Sarver Heart Center Director and Cardiology Chief Dr. Nancy Sweitzer and Henk Granzier report in study published in the Journal of General Physiology the discovery in a lab model that

metformin, a common diabetes drug, could be an effective treatment for heart failure with preserved ejection fraction (HFpEF). Pulmonary researcher Dr. Louise Hecker among three panelists on Tech Launch Arizonas Eureka! Recognizing when Research Gives Rise to Invention luncheon in March at UA BIO5 Institute. Geriatrics Drs. Nima Toosizadeh and Pulmonarys Dr. Christian Bime, pre-pilot project award winners in the Resilience and Independence in Aging Seminar/CHiiLi Program, present on their research Feb. 19 at BIO5. Topics cover frailty and septic shock, and predicting postop outcomes in older adults. Dr. Khadijah Breathett was among nine UA Sarver Heart Center members, trainees or students to share in the 2018-19 Investigator Awards from the center to foster career development. Research National/Global Activities UA geneticist Dr. Christina UA GI Chief Dr. Laukaitis was presented Juanita Merchant March 8 in London with the is elected to National Academy of Medicine

Mendel Medal by the governing council. She also is picked to serve Mendelianum from the Moraas chair of the Board of Scientific Counselors vian Museum of Brno, Czech Republic, for for the National Institute of Diabetes and her contribution to the propagation of MenDigestive and Kidney Diseases, an NIH unit. dels scientific legacy. The date is both International Womens Day and International Dr. Clara Curiel picked to serve as Scientific Mendal Day, which recognizes 19th and Educational Initiative Liaison between Century Friar Gregor Johan Mendel U.S. Melanoma Prevention Working Group and International Dermoscopy Society, based considered the father of genetics. in Austria, for 3-year term. The American Thoracic Society named Dr. Dr. Steve Klotz and infectious diseases fellow Monica Kraft winner of the Elizabeth A. Rich Award, presented during the Womens Dr. Norm Beatty present at Infectious Forum at ATS 2019 in Dallas in May. Diseases Society of America and ASTMH conferences on latest UA research on kissing It recognizes her as a female role bugs and Chagas disease. model, mentor and for her contributions to lung disease research. Research National/Global Activities Drs. John Galgiani, Lisa Shubitz and Neil Ampel present on Valley fever at Vaccine Strategies for Endemic Fungal Pathogens, hosted in Rockville, Md., by

NIH/NIAIDDrs. Galgiani and Shubitz on Vaccines to Prevent Coccidioidomycosis: 60 Years and Counting and Dr. Ampel on Markers of Protective Immunity in Human Coccidioidomycosis. Sleep medicine researcher and pulmonary division chief Dr. Sairam Parthasarathy is among three Strategic Research Award recipients for the American Academy of Sleep Medicine (AASM) Foundation featured in its FOCUS Newsletter. An article on how your office space may affect your health, featuring research by Drs. Esther Sternberg and Casey Lindberg, made No. 3 on the UANews Top 10 Science Stories of 2018with pickups by multiple media outlets across globe. A separate list by Inside Tucson Business/Tucson Weekly included a Lung on a Leaf project by Drs. Ken Knox, Ting Wang and Louise Hecker at No. 7 for its top science stories of the year. Research Contracts & Awards Drs. Joe G.N. Skip Garcia, Francisco Moreno and Sai Parthasarathy are multiplePIs on a $2.15-million R25 research career training grant

from the NIH/NHLBI to address health disparities in treatment of lung and obstructive sleep apnea disorders. Known as the Advanced Respiratory Research for Equity (AiRE) program, it will offer opportunities for up to nine junior faculty. Dr. Rachna Shroff serves as national PI on the first Phase III Randomized Trial of Gemcitabine, Cisplatin, and Nab-Paclitaxel Versus Gemcitabine and Cisplatin in Newly Diagnosed, Advanced Biliary Tract Cancers. NCI and the Southwest Oncology Group activated the trial in December. Drs. Nancy Sweitzer and Sai Parthasarathy Dr. Joe G.N. Skip Garcia also won a $1.84 are co-site PIs on a subcontract through Ohio million NIH/NHLBI award for a study on Novel State University on an NHLBI-funded study Involvement of NAMPT and TLR4 in on Low Flow Nocturnal Oxygen Therapy on Pulmonary Arterial Hypertension (PAH) Hospital Admissions and Mortality in Patients Vascular Remodeling. with Heart Failure and Central Sleep Apnea Omniscient awarded $599,250 to Dr. Bhaskar (LOFT-HF) addressing comorbidity issues in patients suffering from heart failure with Banerjee for his work related to a device to allow Dual View Endoscopy for Colonoscopy. preserved ejection fraction (HFpEF). Research Contracts & Awards As part of the PALISADE Group of clinical investigators, Dr. Tara Carr

co-authors a paper in the New England Journal of Medicine that found in a national clinical trial oral immunotherapy in children and adolescents could be effective in reducing allergic reactions to peanuts by desensitizing them. Dr. Hani Babiker won a $478,125 clinical trial award from Endocyte Inc. for An International, Prospective, Open-Label, Multicenter, Randomized Phase 3 Study of 177Lu-PSMA-617 in Treatment of Patients with Progressive PSMA-Positive Metastatic Castration Resistant Prostate Cancer (mCRPC). The Albert Einstein College of Medicine presented a $472,915 award for a Clinical Coordinating Center (CCC) for NHLBI Prevention and Early Treatment of Acute Lung Injury PETAL Network (Crystalloid Liberal or Vasopressors Early Resuscitation in Sepsis) CLOVERS to Dr. Jarrod Mosier. Dr. Rachna Shroff was awarded a $458,293 clinical trial award for A Phase 1b, Randomized, Open-Label Study of PEGylated Recombinant Human Hyaluronidase (PEGPH20) in Combination with Cisplatin Plus Gemcitabine and PEGPH20 in Combination with Atezolizumab and Cisplati from Halozyme Inc.

Research Contracts & Awards Dr. Franz Rischard received a $453,857 award for A Phase 2, Double-Blind, PlaceboControlled, Randomized Study to Compare the Efficacy and Safety of Sotatercept (ACE011) Versus Placebo When Added to Standard of Care for the Treatment of Pulmonary Arterial Hypertension (PAH) from Acceleron Pharmaceuticals. The UAHS Asthma and Airway Disease Research Centers Dr. Donata Vercelli won a $442,846 grant from NIH/NIAID for a research study on the Role of Gamma delta-17 T Cells in Asthma Protection by Amish Farm Exposure. She also received a $131,243 award from the Helmholtz Center Munich for an Assessment of the Asthma-Protective Properties of Cow Shed Dust Fractions from Bavarian Farms. Dr. Andrew Kraft won a $360,000 Institutional Research Grant from the American Cancer Society. A Phase 1, Open-Label, Multicenter Study to Assess the Safety, Tolerability, and Immunogenicity of mRNA-4157 Alone in Subjects with Resected Solid Tumors and in Combination with Pembrolizumab in Subjects With Unresectable Solid Tumors earned Dr. Julie Bauman a $324,676 award from PPD Investigator Services. Dr. Sophia Airhart was awarded $245,042

for a clinical trial involving An International, Double-blind, Randomised, PlaceboControlled Phase III Study to Evaluate the Effect of Dapagliflozin on Reducing CV Death or Worsening Heart Failure in Patients with Heart Failure from Astrazeneca. Research Contracts & Awards Dr. Emad Elquza got $232,426 from Bristol-Myers Squibb for A Randomized Phase 3 Study of Nivolumab plus Ipilimumab or Nivolumab Combined with Fluorouracil plus Cisplatin Versus Fluorouracil plus Cisplatin in Subjects with Unresectable Advanced. Dr. Daruka Mahadevan received $216,441 for a clinical trial, An Open-Label, Phase 1b Multicenter Study of IBI308 in Subjects with Advanced/Metastatic Solid Malignancies, from Innovent Biologics. A Phase 2 Study of INCMGA00012 in Participants with Squamous Carcinoma of the Anal Canal Who Have Progressed Following Platinum-Based Chemotherapy earned Dr. Aaron Scott a $181,773 clinical trial award from INCYTE. Dr. Marvin Slepian won a $175,653 award for a study on Biomechanical Approaches and Technologies for Enhancing TAVR Outcomes from the State University of New York (SUNY) System.

Dr. Pavani Chalasani was awarded a $161,147 clinical trial for A Randomized Phase II Study to Evaluate Efficacy of T-dm1 with or Without Palbociclib in the Treatment of Patients with Metastatic Her2 Positive Breast Cancer from CRITERIUM. Dr. Frank Chip Brosius won a $168,450 grant as part of his role as site-PI on the Transformative Research In DiabEtic NephropaThy (TRIDENT) national study through the University of Pennsylvania. Research Contracts & Awards Dr. Karl Kern won a $140,371 award from Physio-Control Inc. for a study, Optimizing LUCAS Use for ECPR: 1) Time to Institute LUCAS at Scene of Outof-Hospital VF Cardiac Arrest Drs. Akinlolu Ojo and Titilayo Ilori received $114,301 from U Ghana for ongoing studies in the H3Africa Kidney Disease Research Network. A study of ADAM8: A Novel Proteinase that Protects against Second-hand Smokeinduced COPD earned Dr. Francesca Polverino a $108,500 award from the Flight Attendant Medical Research Institute.

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