Betulin: Protective Compound from White and Paper Birch

The Betulin Project Fall Semester CH 203, 2014 Boston University Instructor: Prof. John K. Snyder Laboratory Fellow: Dr. Ya Zhou, PFF Betulin Group Meetings Thursdays, 3 pm

Betulin Laboratory: Alternate Fridays, 1 - ? pm Betulin: Protective Compound from White and Paper Birch Anti-Melanoma Betulinic Acid

Lipinskis Rule of Five 1)No more than 5 Hydrogen Bond Donors (NH and O-H) 2)No more than 10 Hydrogen Bond Acceptors (all Ns and Os) 3)MW less than 500 4)cLogP = 5 or less

Betulinic Acid Derivatives Anti-Melanoma Anti-HIV

Last Years Progress Five Experiments to here! Allobetulin Analogues

Five Experiments to here! Ultimate Targets From Betulin

From Allobetulin

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