+ Immune System Day 1 + Think Pair Share GROUP DISCUSSION WILL FOLLOW! 1.Why do you think the human body makes a great place for disease causing organisms to grow? 2.What are some examples
of organisms that cause disease? 3.What are some ways diseases are spread? 4.In spite of being under constant attack by pathogens, we do not get sick all the time. What organ system is responsible for this? + What is the essential question? Why is the immune response considered a specific defense
against pathogens, while the inflammatory response is considered a nonspecific defense? + Write what is in RED draw tables when necessary + Date: 12/02-12/05 Topic: Immune System Day1 Learning Target: Explain the basic functions of the human immune system, including
specific and nonspecific immune response What Is A Disease? A disease is any change, other than an injury, than disrupts the normal functions of the body. Disease-causing germs are called pathogens.
Pathogens diseases causes + What are the basics? Homeostasis Diseases can disrupt this stability.
Your immune system is the organ system that protects your body from disease. Your body has three different lines of defense against pathogens, or disease causing agents. + Immune System +What are the two types of immune defense?
The immune system includes two general categories of defense mechanisms: Nonspecific defenses guard against infections by keeping most things out of the body. Combines physical, chemical and mechanical factors
Specific defenses track down harmful pathogens that have managed to break through the bodys nonspecific +Engage: Student, differentiate between nonspecific and specific lines of defenses. Student, build upon previous students answer.
Student, challenge or support previous students answer. Student, combine what your previous classmates mentioned Engage + Student, what is our bodys first line of defense? :
Student, construct an analogy for the bodys first line of defense. Student, unpack previous students answer. Student, what is our bodys second line of defense? Student, construct an analogy for the bodys first line of defense.
Student, unpack previous students answer. Student, what is our bodys third line of defense? Student, construct an analogy for the bodys first line of + What is the essential question? Why is the immune response considered a specific defense
against pathogens, while the inflammatory response is considered a nonspecific defense? +What is the role of the cardiovascular system on the immune system? Circulatory system: a network of veins, arteries and blood vessels that transports blood to and from the heart. circulatory system helps to fight the
infection by transporting the immune systems specialized cells to the source of the infection. Lymph nodes WBC production The Blood flow Circulatory System
DEFENS E phagocyte, B cell, T cell, spleen, thymus, antibodies Immune system + Body has 3 lines of defense: 1st line: non-specific 2nd line: non-specific 3rd line: specific
What do you think they are? + st 1 Line of Defense: Barriers to Infection To cause disease, a pathogen must invade the body. Your body has barriers to keep this
pathogens out. WAIT TO WRITE NOTES FOR NEXT SLIDE. + Example of 1st line of defense Role 1) Skin (non-specific) Most important nonspecific defense Acts as a barrier to infection Engages in chemical warfare 2) Mucus
membrane (non-specific) Covers internal body surfaces that come in to contact with the environment Contains glands that secrete mucus Traps pathogens in the nose and throat Contain lysozymes (enzymes + Example of Nonspecific Defense 3) Cilia
(non-specific) Role Found in the respiratory tract Helps to trap pathogens. Stomach acid and digestive enzymes destroy many pathogens that make their 4) Body way to your stomach. Secretions Sweat/Tears/Oil/ Oil and sweat glands in the skin produce an acidic environment that kills many Acid (non-specific) bacteria. Antibacterial enzymes are found in saliva
and tears WAIT TO WRITE NOTES FOR NEXT SLIDE. + 2nd Line of Defense: Inflammatory Response The inflammatory response is the bodys response to tissue damage. As soon as pathogen enters your body, damaged tissue releases chemical signal. If infection persists, body may increase temperature resulting in a fever.
Why? WAIT TO WRITE NOTES FOR NEXT SLIDE. + 2nd Line of Defense: Phagocyte Phagocytes ingest bacterial germs through phagocytosis. WAIT TO WRITE NOTES FOR NEXT SLIDE. + nd 2 Line of Defense: Interferon
Interferons are a protein that has the property of inhibiting virus replication. Inflammatory Response + Example of 2 line of nd defense 1) Phagocyte (macrophage)
(non-specific) 2) Interferon (non-specific) Role Protein released by animal cells Phagocytes ingest bacterial germs through phagocytosis. Protein released by animal cells Has the property of inhibiting virus replication. 3) Inflammatory response (non-specific)
Reaction to tissue damage caused by injury or infection. Produces millions of White Blood Cells, to fight the infection or injury 4) Fever (non-specific) Releases chemicals that increase the core body temperature An elevated temperature slows down or stops the growth of pathogens. WAIT TO WRITE NOTES FOR NEXT SLIDE. + rd 3 Line of Defense: Immune Response
The immune response attacks specific pathogens using specialized cells and proteins. T cells, B cells, and antibody + 3rd line of defense Example of Role 1) T cell
White blood cells that attack and kill harmful bacteria. White blood cells that make antibodies. (specific) 2) B cell (specific) 3) Antibody (specific)
Y-shaped protein that attaches to a specific foreign substance, known as an antigen. + Now that you know the definitions highlighted, use your notes and knowledge of the immune system to answer this as a group. (3 minutes) I WILL CALL ON YOU FOR RESPONSES!!! What is the essential Why is the immune response question?
considered a specific defense against pathogens, while the inflammatory response is considered a nonspecific defense? + The Inflammatory Response 2nd Line of Defense ; Nonspecific + The Immune Response 3rd Line of Defense ; Specific +
The Essential Question Answered Specific Defense Role of immune response immune response is targeted toward pathogens it remembers Memory cells continue to patrol the bodys tissues, circulating through the blood and lymph for long
periods of time and responding quickly against pathogens they recognize Nonspecific Defense Role of inflammatory response inflammatory response can inhibit the growth of pathogens and stimulate macrophage action, but the inflammatory
response is not selective + Lines of Defense (30 minutes) Immune system dominoes + Independent Practice COMPLETE SILENTLY 10 minutes! + Exit Ticket COMPLETE SILENTLY 10 minutes!
+ Homework: Venn-Diagram Due NEXT CLASS!!!!!! Nonspecific Response vs. Specific Response Compare nonspecific response vs. specific response by completing the Venn diagram. Write similarities where the circles overlap, and differences on the left and right sides. Be ready to share! Nonspecific Response ______________ ______________ ______________ ______________ ______________
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