Selected Viral Diseases Updated March 2015 J. D. Hendrix Selected Viral Diseases A. B. C. D. E.
Influenza Diseases Caused by the Herpes Family Viral Hepatitis Human Immunodeficiency Virus Miscellaneous Viral Diseases A. Influenza Properties Member of the Orthomyxovirus family Enveloped RNA virus Two envelope proteins
Hemagglutinin and Neuraminidase Segmented RNA 8 segments; packaged into helical nucleocapsids Antigenic variation & genetic exchange lead to the appearance of new strains; requires use of different vaccine combinations each year A. Influenza
Symptoms & Complications of Influenza Respiratory Tract Symptoms Fever Neurological Complications: Guillain-Barr Syndrome Reyes Syndrome B. Diseases Caused by the Herpes Family Properties of the Herpes Virus Family Large, enveloped DNA viruses
Icosahedral capsids DNA replicates in the nucleus of host cells Cells may become permanently infected Host chromosomes may be altered Herpes infections associated with certain cancers B. Diseases Caused by the Herpes Family Herpes Simplex
Two major strains Type I: Oral Herpes Type II: Genital Herpes Skin lesions form at site of the infection Virus travels along sensory neurons to ganglia, where it remains During times of stress or weakened immunity, virus may travel along same neurons to re-infect the initial skin sites
B. Diseases Caused by the Herpes Family Herpes Simplex (cont.) Other complications Herpes encephalitis Congenital herpes Treatment: Acyclovir
B. Diseases Caused by the Herpes Family Chicken pox & Shingles Cause: Varicella-zoster virus Chicken pox symptoms Shingles symptoms Treatment Chicken pox vaccine Connection to Reyes syndrome B. Diseases Caused by the
Herpes Family Infectious mononucleosis Cause: Epstein-Barr virus Infectious mononucleosis Lymph node swelling; fever; fatigue Heterophile antibody production Monospot Test Other complications Burkitt's Lymphoma Chronic Fatigue Syndrome??!?
B. Diseases Caused by the Herpes Family Cytomegalovirus Mild symptoms in otherwise healthy individuals Major complications Miscarriages when contracted during pregnancy Severe infections in AIDS patients Major cause of blindness in AIDS patients
C. Viral Hepatitis Hepatitis A Also known as: Infectious hepatitis Short-incubation hepatitis Viral Properties Picornavirus Family Small nonenveloped RNA viruses Family includes common cold (rhinovirus) & polio viruses
C. Viral Hepatitis Hepatitis A (cont.) Transmission: Virus particles are present in the stool Fecal-oral route via contaminated food or water C. Viral Hepatitis Hepatitis A (cont.) Symptoms:
Two to four week incubation period Nausea, vomiting, fever Abdominal pain Jaundice in many but not all cases Duration usually several weeks C. Viral Hepatitis Hepatitis A (cont.) Treatment & Prevention: Prolonged rest Hepatitis A Immune Globulin
Hepatitis A vaccine C. Viral Hepatitis Hepatitis B Also known as: Serum hepatitis Long-incubation hepatitis C. Viral Hepatitis Hepatitis B (cont.) Viral properties:
Hepadnavirus family Nucleocapsid consists of DNA surrounded by hepatitis B core antigen (HBcAg) The core is surrounded by a lipoprotein envelope containing the hepatitis B surface antigen (HBsAg) The virus has also been called the Dane particle Large amounts of excess HBsAg are found in the serum & may be detected serologically C. Viral Hepatitis Hepatitis B (cont.)
Transmission: Contact with infected body fluids Blood, blood products, semen, vaginal secretions C. Viral Hepatitis Hepatitis B (cont.) Symptoms: Incubation period: four weeks - six months Nausea, fever Dark urine & clay-colored stools Abdominal tenderness
Jaundice Duration of symptoms: 3 - 4 months About 10% of patients remain carriers for several months C. Viral Hepatitis Hepatitis B (cont.) Treatment & prevention Hepatitis B Immune Globulin Hepatitis B vaccination
C. Viral Hepatitis Non-A non-B (NANB) Hepatitis Hepatitis C NANB serum hepatitis Enveloped virus of the Flavivirus family Transmission & symptoms similar to B Delta hepatitis A small defective RNA virus that requires coinfection with Hepatitis B to replicate Co-transmitted with Hepatitis B
C. Viral Hepatitis Non-A non-B (NANB) Hepatitis (cont.) Hepatitis E NANB infectious hepatitis A small nonenveloped RNA virus of the calcivirus family Transmission & symptoms similar to Hepatitis A D. Human Immunodeficiency Virus
Viral Properties A retrovirus An enveloped RNA virus that replicates through a DNA intermediate The DNA intermediate is synthesized by reverse transcriptase: an enzyme that makes a DNA molecule using an RNA template The DNA intermediate is spliced into host chromosomes, making the infection permanent D. Human Immunodeficiency
Virus Viral Properties (cont.) Host cells for HIV: CD4+ cells Helper T (T-4) lymphocytes Macrophages Damage to the helper T cell population cripples
the immune system of the host D. Human Immunodeficiency Virus Transmission Contact with infected body fluids Blood, blood products, semen, vaginal secretions, breast milk D. Human Immunodeficiency Virus
What is the difference between HIV & AIDS? HIV: the Human Immunodeficiency Virus The cause of AIDS Also known as: HTLV-III and LAV Two known types: HIV-1 and HIV-2 AIDS: Acquired Immune Deficiency Syndrome Catastrophic immune system failure caused by HIV infection Symptoms & cases are usually defined by the CDC case surveillance definition
D. Human Immunodeficiency Virus Symptoms & Secondary Infections Associated with AIDS Acute Infection Fever, lymph node swelling, aches, fatigue, flu-like or mono-like symptoms Persistent Generalized Lymphadenopathy Lymph node swelling for greater than 6 months in two or more body areas (excluding the groin)
Often an early manifestation that AIDS has developed D. Human Immunodeficiency Virus Symptoms & Secondary Infections Associated with AIDS (cont.) Constitutive Illness Weight loss, persistent fever, diarrhea Cancers Kaposis sarcoma
Certain lymphomas D. Human Immunodeficiency Virus Symptoms & Secondary Infections Associated with AIDS (cont.) Bacterial Secondary Infections Mycobacterium Listeria Salmonella Mycoplasma
many others D. Human Immunodeficiency Virus Symptoms & Secondary Infections Associated with AIDS (cont.) Fungal Secondary Infections Candida and others Protozoan Secondary Infections Toxoplasma gondii Cryptosporidium
Pneumocystis carinii D. Human Immunodeficiency Virus Symptoms & Secondary Infections Associated with AIDS (cont.) Viral Secondary Infections Herpes simplex Cytomegalovirus Many others
Treatments Inhibitors of DNA replication Protease Inhibitors E. Miscellaneous Viral Diseases Miscellaneous Pneumotrophic Viruses Rhinovirus Adenovirus Respiratory Syncytial Virus
E. Miscellaneous Viral Diseases Miscellaneous Dermotrophic Viruses Measles (Rubeola) Rubella
Beta 2: Broncodilatação - vasodilatação - pequena diminuição da resistência periférica - aumento da glicogenólise muscular e hepática - aumento da liberação de glucagon - relaxamento da musculatura lisa uterina - tremor muscular. Beta 3 - Termogênese e lipólise.
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