* L Baker et al AACR 2002 **Can Res 50:6344 1990 INTERGROUP SARCOMA COMMITTEE HER2 and Cox-2 Expression in Synovial Sarcomas Her2/neu Cox-2 EGF-R EXPRESSION AND INHIBITION IN MPNST Intense membrane staining EGF-R inhibitors DeClue et al JCI 2000 ICAS STUDIES Metastatic Disease ICAS # Sarcoma
Target Inhibitor Prior Rx S0330 MPNST EGF-R erlotinib N S0345 DFSP PDGF-R imatinib Y S0346 Synovial
HER2* trastuzumab Y S0505 STS VEGF sorafenib Y ICAS STUDIES Metastatic Disease ICAS # Sarcoma Target S0423 Chondro
MTAP pemetrexed Y VEGF bevacizumab N imatinib N S0502 GIST S0416 (COG) GIST(<30) kit S0406 (RTOG) STS COX-2 Inhibitor celocoxib
EWS0031(COG) Ewings dose density chemo Prior Rx Y N ICAS STUDIES Primary Disease ICAS # Sarcoma Target Inhibitor Prior Rx S0344 Chondro local surgery
telomerase S0405 (COG) Synovial bcl-2 anti-sense S0404 (ACSOG) STS ACOSOG STS array/microscopy retroperitoneal XRT N N N ICAS NEW ERA 2000 MOLECULAR REDEFINITION IMPROVE PRIMARY MANAGEMENT IDENTIFY TARGETED THERAPIES
Nonautonomous elements. Gene(s) Most genomes contain multiple transposon families. Each family contains autonomous and non-autonomous elements. Autonomous elements encode their own moving competency. Non-autonomous elements are moved by other elements.
Group Quiz #2 Section 9.5 Concentrations of Solutions Concentration Molarity (One type of concentration) Example Preparing molar solutions Group Quiz #3 Dilution Dilution Examples Number of Ions in Solution Number of Ions in Solution Section 9.6 Aqueous Reactions and Chemical...
CHAPTER 3:PHYSICAL EVIDENCE. Learning Objectives: List the common types of physical evidence found at crime scenes. Explain the difference between the identification and comparison of physical evidence. Define individual and class characteristics. Give examples of physical evidence possessing these characteristics.
Merchant buys raw fiber Women and children clean, sort, spin Merchant collects yarn, pays, takes it to weaver Men weave Merchant pays and picks up woven cloth takes it to the fuller Fuller shapes and cleans Dyer…dyes Merchant sells finished...
Both trade impediment (distance) and preference factors (common border, common language, and so on). Based on the endowment-based new trade model (Dixit and Stiglitz, 1977) Bilateral trade is an increasing sum of factor income G, relative size S, and the...
The Grasshopper: the digestive system Grasshoppers feed on plants so their mouthparts are modified for cutting & chewing plant materials The labrum & labium are mouthparts that function as upper & lower lips They hold the food in place so...
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