PCOS How Long Can We Ignore It? - UC Davis Health

PCOS How Long Can We Ignore It? - UC Davis Health

How Does Body Maintain Normal Blood Sugar? a Insulin Resistance and Its Consequences Sidika E. Karakas, M.D

Professor and Chief Division of Endocrinology, Diabetes and Metabolism Symptoms of High Sugar (Diabetes)

Symptoms of Low Sugar (Hypoglycemia) Blood Sugar Homeostasis Pancreas

Amount of Insulin We Need Depends on What We Eat Meals containing sugars and simple carbohydrates require more insulin Amount of Insulin We Need also Depends

on Our Body Presentation of Insulin Resistance Blood Sugar: 80 80

Insulin: 30 10

Larger the Waistline Higher the Need for Insulin (Insulin Resistance) Skin Signs of Insulin Resistance Insulin Response to Sugar Intake

Insulin resistant Normal INSULIN RESISTANCE NEED for EXCESS INSULIN

PANCREAS FATIGUE TYPE 2 DIABETES Common Cause of Insulin Resistance in Females: PCOS

Insulin Resistance Cysts in the Ovaries Polycystic Ovary Syndrome (PCOS)

Most common endocrine condition in women Affects 1 out of 16 women 8% of AA; 5% of White Causes irregular periods Excess facial or body hair

Menstrual cycles are a vital sign Andrea Dunaif, MD. What is normal? More than 35 days in between two periods is considered too long One year after having their first period,

65% of adolescents have more than 10 periods / year Three years after, more than 90% have >10 menses /year Difficulty in getting pregnant

Excess Hair Weight gain Acanthosis Infrequent periods Age 10

30 20 What can we do about it We can do a lot Weight control

Insulin sensitizers (metformin) Medicines for acne, facial hair and body hair Clinical Findings of PCOS Effects of Weight Loss on Fertility

33 PCOS patients 25 lost 5% weight 11 of these lost >10% 15 women ovulated P.G. Crosignani et al. Human Repro 18:1928, 2003.

Cysts in the ovaries decreased with weight loss Ovarian volume decreased by 18% with 5% weight loss 25% with 10% weight loss Follicle number decreased

from 23.511.5 to 19.9 9.9 with 5%, to 18.3 7.5 with 10% weight loss Healthy Ways to Decrease Insulin Resistance

Decrease simple sugar intake DO NOT DRINK SWEETENED DRINKS Dont overeat Walk, do sports 150 min/wk to maintain weight 250 min/wk to lose weight

Talk to your parents and doctor If you dont have monthly periods If you are getting excess hair Treatment of Facial Hair Suppress ovarian androgen production contraceptives

Treatment of Facial Hair Block androgen receptor (sprinolactone) Block conversion of testosterone to DHT (finasteride)

Management Planning Oral Contraceptives Lipids Insulin resistance Diabetes

Pregnancy Pregnancy Facial Hair Difficulty in getting pregnant

Excess Hair Weight gain Acanthosis Infrequent periods Age 10

30 20 [email protected] http://www.ucdmc.ucdavis.edu/

internalmedicine /endocrinology/Research.html

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