EOHSI is jointly sponsored by UMDNJ Robert Wood Johnson Medical School and Rutgers, The State University of New Jersey.
Dermal Toxicology Specialty Section
What is Dermal Toxicology?
The Dermal Toxicology Specialty Section
The skin, as the largest and most visible organ of the body, is
subject to constant exposure to a wide range of materials.
These materials may be natural or synthetic and can be
biological, chemical or physical in origin. The skin itself may
be the target of these agents or they may be absorbed into the
body to cause toxicity in other organs. Dermal toxicology is,
therefore, the study of the adverse reactions of the skin
resulting from such exposures.
The Dermal Toxicology Specialty Section provides an
opportunity for interactions between scientists involved in
skin toxicology, pharmacology and basic skin biology. The
areas of research encompassed by Dermal Toxicology
include both mechanistic studies of toxicity to the skin itself
as well as toxicity to other organs due to absorption through
the skin. Of particular interest is the application of these
results to the production of risk assessment models for
cutaneous exposure to a wide range of potential toxicants,
ranging from environmental agents to synthetic chemicals to
cosmetics. As results, research within Dermal Toxicology has
broad applications in such areas as carcinogenesis, alternative
model systems, pharmacokinetics and regulatory issues.
A main focus of the research within the field of dermal
toxicology is involved in predicting such reactions when the
skin is exposed to a particular agent. Cutaneous risk
assessments are a primary tool used in the cosmetics industry
as well as determining both occupational and environmental
In order to promote research within the field, the Dermal
Toxicology Specialty Section offers student and postdoctoral awards at the SOT Annual Meeting for accepted
abstracts as recognition for exceptional research involving
skin toxicology and pharmacology. In the past, a generous
contribution from the publishing company, Taylor and
Francis, has supplemented these awards with a check and a
subscription to Cutaneous and Ocular Toxicology.
Dermal toxicology is also a major factor in the development of
topical pharmaceuticals. Transdermal delivery of medication
requires penetration of the skin barrier so as to maximize
absorption while minimizing local irritation and toxicity. The
formulation of medications targeted to the skin must also
achieve this balance. In addition, the application of materials
to the skin must be accounted for in pharmacokinetic models
for transport of substances throughout the body.
The Officers of the DTSS
Access to people in the field
Robert L. Bronaugh, Ph.D.
Interests: The percutaneous
absorption and metabolism
of topically applied chemicals
James N. McDougal, Ph.D.
Wright State University
Interests: skin absorption,
molecular biology of skin irritation,
systems biology, and biologicallybased
Cindy A. Ryan
Procter & Gamble
Interests: The development of a
cell-based in vitro alternative
method for skin sensitization
Debra Laskin, Ph.D.
Interests: Immunotoxicology, inflammation,
and immune mechanisms in liver and lung lnjury
Bill Reifenrath, Ph.D.
Interests: Topical drug development,
models for skin absorption, chemistry of
Nancy Monteiro-Riviere, Ph.D.
North Carolina State University
Interests: Dermatotoxicology, chemical absorption
and nanomaterial interactions with skin both in
vivo and in vitro
Interests: Mechanisms of ultraviolet
light signal transduction
Cosmetics and Lotions
Take the Skin Quiz
Why take the Skin Quiz?
1. Its easy!
2. Youre guaranteed to pass!
3. You dont have to study!
4. Youll be registered to win a memory stick!
All participants will be entered into a drawing to win a
1 G memory stick. The winner will be announced at
the DTSS Annual Meeting on Wednesday, March 5
from 6:00 to 7:30 pm.
You have to be in it to win it!
Examples of dermatotoxic materials:
The Skin Quiz
David W. Hobson, Ph.D., DABT
H&H Scientific Services, LLP
tissue repair and wound healing product R&D,
risk assessment and toxicolkinetics /
Basic research in skin biology also provides ample
opportunities for investigation in dermal toxicology. This
research offers a more complete understanding of the
molecular mechanisms underlying the processes involved in
the generation of these adverse reactions. With this
information, improved models could be produced that allow
for more accurate predications of potential toxicity as well as
provide potential molecular targets for the prevention and
treatment of these reactions.
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