Welcome to Advanced Physiology of Animals ANSC 3405

Welcome to Advanced Physiology of Animals ANSC 3405

Welcome to Advanced Physiology of Animals ANSC 3405 Dr. John McGlone and others Lectures: Tue-Thur 12:30-1:50 pm Labs: Mon 3:00-5:50 pm Todays Outline I. Introductions A. II.

Instructors, students and pictures Syllabus A. B. Class format (lectures and lab) Advice on preparing for class III. Lecture A. B. C. Principles of physiology Homeostasis

Body size Introductions Dr. John McGlone Dr. Mhairi Sutherland Lindsey Hulbert, graduate student Students Name Where you are from Major Career Goals Student pictures

Syllabus Objectives Overview of animal physiology history, complexity and integration of animal physiology research Pre requirements Ansc 2202 (Anatomy) or equivalent > 3.0 GPA Syllabus Lecture format and materials Lectures, reading and research assignments, handouts, homework, quizzes and exams Class Website:

http://www.depts.ttu.edu/porkindustryinstit ute/Advanced%20Physiology/Advanced_P hysiology.htm Print lectures prior to class for note taking Syllabus Textbook Most of the book will be covered Lab notebook With duplicate carbon pages to turn in Syllabus Grading Procedures: Normal grading scale (90% = A, etc.)

Source of points Hour exams (3) 300 (37.5%) Quizzes, homework, projects 100 (12.5%) Final exam (comprehensive) 200 (25%) Laboratory 200 (25%) ----------------Total 800 (100%) Syllabus Exams and quizzes/assignments 3 Exams on previous material Final exam comprehensive Assignments must be turn in on time

25% loss of points per late day Missed quizzes can only be made up with excused absences Attendance Mandatory for laboratory Lecture: 2 excused absences, 20 point loss for each class missed unexcused If you will be missing more than 3 lectures, then you may need to reconsider taking this course Syllabus Laboratory Physiology/surgery laboratories Animal care and experiments outside of class

Laboratory write-ups and research Assignment (Towards the end of the year) of a topic to present All laboratories will need to be written up (instructions and questions will be provided) Advanced Physiology of Animals ANSC 3405 Lecture 1 Major Branches of Physiology and Medicine

Cardiovascular Renal Respiratory Gastrointestinal Neuroscience Endocrinology Reproductive Orthopedic (Bone and Muscle) Major Branches of Physiology

Comparative Physiology Environmental Physiology Evolutionary Physiology Developmental Physiology Cell Physiology/Biology Biological function at each level of organization Organism Organ system Organ and Cellular Macromolecular level level level

Tissue levels level 0.2 mm 20 m 2 m 200 nm Cells 2 nm 0.2 nm Molecules

Organelles (See Figure 1.1 page 6 in text) 20 nm Molecular level Atoms Physiology is an Integrating Science How did a system evolve? What were the survival advantages for this feature? How does ontogeny reflect evolution?

Ontogeny recapitulates phylogeny Brief History of Physiology 470 B.C. Socrates 384 B.C. Aristotle A.D. 1500 Galileo (1568-1657) Marcello Malpighi (1628-1694) 1600 Microscopic biology/physiology

1700 Antoine Lavoiser (1578-1657) Chemistry & metabolism: oxygen consumption William Harvey (1578-1657) Brief History of Physiology 1800 1900 2000 The rapid expansion of our modern knowledge in physiology began in

the late 1800s 1920-1950s Phase of classic physiology research 1950-1980 Phase of biochemical discoveries: DNA, Enzymes, Receptors, Hormones, etc. 1980-present Transgenics, cloning, knock-outs, xenotransplantation, and much more. Homeostasis The tendency of organisms to regulate and maintain relative internal stability Claude Bernard (1872) The milieu interieur Constancy of the internal environment is the

condition of life Walter B. Cannon (1871-1945) Sympathetic flight or fight response Homeostasis Feedback and Control Negative feedback systems and loops Positive feedback systems and loops Conformers and regulators Negative Feedback Negative Feedback Disturbance Controlled Output

System (Read page 11 in text) Sensor Error Signal Inverting Amplifier Positive Feedback Positive Feedback Disturbance +

Controlled Output System Sensor Error Signal Amplifier Units of Measure Metric System in Science Liquid- Liter, L Solid- Grams, g Length- Meters, m Molecule concentrationmoles

1012 Tera T 109 Giga G 106 Mega M

103 Kilo k 10 Hecto h 10 Deka da

10-1 Deci D 10-2 Centi c 10-3 Milli

m 10-6 Micro 10-9 Nano n 10-12 Pico

p 10-15 Femto f 10-18 atto a Converting Units Conversion of units is very

important in any field 1 cc = 1mL 5 mL = 1 tsp 1 kg = 2.2 lb=35.3 oz 1 m = 39.37 in=3.28 ft 1m2 = 10.76 ft2 2.24cm = 1in 3.28 ft = 1m http://www.onlineconversion.com/ Size, volume and mass Smaller bodies have more mass per unit of surface area Smaller bodies exchange heat more with the environment than larger ones

This concept works for cells as well as animals and objects Size, volume and mass 100 90 80 BMR 70 60 50 40 30 20

10 0 Body wt, kg Surface Area Calculations Area, m2 = 0.1 wt0.667 (wt, in kg) Calculate surface area for: 1000, 30 g mice = ? 1, 30 kg pig = ?

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