The DWMRI/MRS Glioma Imaging Protocol Faculty Research Meeting
The DWMRI/MRS Glioma Imaging Protocol Faculty Research Meeting 6/23/08 Lars Ewell University of Arizona Medical Center Department of Radiation Oncology The DWMRI/MRS Glioma Imaging Protocol I. II. Introduction Radiation Induced Necrosis/Disease III. Imaging Protocol
IV. Initial Data V. Conclusion 2 The DWMRI/MRS Glioma Imaging Protocol: Introduction Designed to study whether or not Diffusion Weighted MRI and Magnetic Resonance Spectroscopy (MRS) can differentiate between radiation necrosis and recurrent disease. Enrolled first patient 3/23/07. See http://www.u.arizona.edu/~lewell/protocol/index.html 3 DWMRI/MRS Protocol: Enrollment Criteria Patients eligible to enroll if they have a
reasonable risk of suffering from RIN. Published data1 indicate that patients receiving a dose of 60Gy in 30 Fx have between a 5 and 24% chance of developing RIN. 1) Kumar et al., Malignant Gliomas: MR Imaging Spectrum of Radiation Therapy and Chemotherapy Induced Necrosis of the Brain After Treatment, Radiology, 217, 2, November 2000. 4 Imaging Protocol: Enrollment Criteria Biological Equivalent Dose (BED) used to determine enrollment criteria for hypofractionation and SRS. d / BED = nd(1 +
) with n the number of fractions, d the dose, and the linear quadratic constants. 5 x 6Gy required for hypo fractionation, 21Gy for SRS. 5 Imaging Protocol: Enrollment Criteria Radiation Type Number of Fractions Minimum Radiation (Gy) SRS
1 21 Hypo-fraction 5 30 Normal Fraction 30 60
Re-treatment varies varies 6 Imaging Protocol: Scan Data Three MRS slices, one cm/slice: One centered on lesion, one superior and one inferior. Voxel size ~ 4cc. Set of three diffrad DWMRI scans with b-values: 0, 520 and 850 s/mm2. Set of two echo planar DWMRI scans with b-values: 0, 1000 s/mm2. Scan time approximately < one hour.
Engg. Technology RTU Replacement 2019 (May 8, 2019) Welcome and Introduction . Robert Kuhn, Sr. Buyer. Omar Alhyari, Project Manager. Rachel Stalker from Strategic Energy Solutions. Other University Attendees. Sign-in Sheet will be posted to the website.
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