Resistencia bacteriana - WordPress.com

Resistencia bacteriana - WordPress.com

RESISTENCIA BACTERIANA IMPERMEABILIDAD: La mayora de los antibiticos necesitan penetrar la membrana celular para ejercer su accin en el interior de la clula.

Peptidoglicano Porinas MODIFICACIN ENZIMTICA O DESTRUCCIN Las bacterias tienen la capacidad de producir enzimas que inactivan o modifican los antibioticos Beta- lactamasas: inactiva el

anillo beta-lactmico de penicilinas, cefalosporinas, carbapenemes y monobactam, mediante su hidrlisis. Ambier, Jaurin y Grundstrom queda propuesta una clasificacin basada en el peso molecular, espectro y grado de homologa en secuencias de aminocidos, postulndose las cuatro clases: Clase A: Enzimas serma con actividad preferentemente penicilinasas. Clase B: Metaloenzimas con actividad preferentemente cefalosporinasas.

Clase C: Cefalosporinasas cromosmicas de bacterias Gram negativo. Clase D: Enzims serinas que hidrolizan oxaciclina. *1989 Bush, realiza una clasificacin basada en caractersticas bioqumicas, fisicas, espectro de hidrlisis y espectro de inhibicin, estableciendo 4 grupos: Grupo I Enzimas serina, con actividad preferentemente cefalosporinasas, no inhibidas por cido clavulnico pero inhibidas por aztreonam. Grupo II Enzimas serina inhibidas por cido clavulnico, incluyendo 6 subgrupos. Grupo III Metaloenzimas no inhibidas por cido clavulnico. Grupo IV Penicilinasas no inhibidas por cido clavulnico.

Betalactamasas Macrolidos esterasas Epoxidasas Transferasa s

Al analizar la resistencia por antibitico, fueron siete los responsables de 80% de la resistencia observada en los seis hospitales estudiados: gentamicina (Gm), ampicilina (Am), ciprofloxacina (Cip), amikacina (Ak), cefalotina (Cf), piperacilina (Pip) y trimetoprim-sulfametoxazol (T/S). Dos aminoglucsidos, Ak y Gm, presentaron la resistencia ms alta

(>20%) en cuatro de las seis instituciones. La resistencia a la Cip sobrepas 30% en tres de los hospitales estudiados Referencias: Surveillance of antibiotic utilization and bacterial resistance profiles in tertiary level hospitals in Mexico City Lilia Benavides-Plascencia, M en CI; Alejandro Leonardo Aldama-Ojeda, M en CII; Hctor Javier Vzquez, Dr en CII

IDepartamento de Sistemas Biolgicos, DCBS, UAM-X Universidad Autnoma Metropolitana, Unidad Xochimilco. Mxico, DF, Mxico IIDepartamento de Sistemas, DCBI, UAM-A, Universidad Autnoma Metropolitana, Unidad Azcapotzalco. Mxico, DF, Mxico Antibiotics Resistance Mechanisms: can we achive abalnce between use and akuse of antibioies and then reduce bacterual resistence tothese medications? CRISTINAEUGENIACABRERA ALAIX MSc1 CAROLINA MEJIA OTERO2 Fecha de recibo: Abril 15 de 2008 ,Fecha de aceptacin: Junio 18 de 2008

Las bases farmacologicas de la TERAPEUTICA Goodman & Gilman, laurece L. Brunton, john S. Lazo, Keith L. Parker,11 ED, CAP 42, pp1045-1098

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