Welcome to the OCTOBER 2013 edition of the

Welcome to the OCTOBER 2013 edition of the

Welcome to the OCTOBER 2013 edition of the PRED4 newsletter Many thanks for recruiting to the PRED4 study, we are recruiting well but need an extra drive to recruit patients into the TNF and PPI arms of the study. The most successful way to increase recruitment is to involve your neurology, rheumatology and dermatology (TNF) and renal (PPI) consultants. Please see a reminder below of some of the tips to assist you with recruiting to the Anti-TNF and PPI arms. Thank you all very much for your efforts to date. The PRED4 study incorporates: TIP Thiopurine induced Pancreatitis; TIM Thiopurine induced myelosupression; PPI PPI induced nephrotoxicity ; TNF Anti- TNF induced demyelination Please can we ask you to send in your CRF is being used. forms as soon as possible. You may also use the eCRF is being used. for entering clinical data www.ibdresearch.net. Please contact the team to obtain a user name . Thank you. Tips which we have found helpful to identify patients Talk to your Neurologists, Rheumatologists and Dermatologists (and Neurophysiology) Contact imaging for MRI scans and cross check with codes for UC (K51) and CD (K50); Arthropathies (M00-M25) and Spondyloarthropathies (M45-M49); G35-G37 (Demyelinating diseases of the CNS); or other conditions for which the Anti-TNF is being used. is being used. Codes for identifying patients with PPI induced renal failure: M13.1 (Percutaneous needle biopsy of lesion of kidney) + N10 and N12 (Acute tubulo-interstitial nephritis) OR Y53 (Side effects from Gastrointestinal drugs) If you have clinic letters available in an electronic format, ask your IT department do a search for patients seen by the Renal team with PPI / omeprazole etc in the Diagnosis or Medical history sections. We have found that raising the profile of the Anti-TNF/ PPI study to our neurology and renal colleagues has also been very successful. E.g. MDT meetings or at lunch time presentations. We can also provide you with laminated inclusion criteria to place in clinic rooms. IBD Research Team and how to contact us: Marian Parkinson - Tel: 01392 403812 [email protected] And Clare Heard - Tel: 01392 403818 [email protected] Dr Tariq Ahmad (Chief Investigator) E-mail: [email protected] Claire Bewshea IBD Research Project Manager E-mail: [email protected] Tel: 01392 406928 Mobile: 07828146468 Junior doctors: Drs Abhey Singh (TNF is being used.) [email protected] ; Graham Heap (TIP/TIM) [email protected] Noami Edney [email protected] (PPI) PRED4 Hospital sites - recruitment numbers taken from the date sample tested in laboratory - up to 3 rd Oct 2013 Royal Devon & Exeter Hospital Guy's Hospital, London Southampton General Hospital Royal Derby Hospital F is being used.lorence, Italy Hull Royal Infirmary, East Yorkshire Nottingham University Hospitals Royal Berkshire Hospital, Reading Western General Hospital, Edinburgh Addenbrooke's Hospital, Cambridge Orebro University Hospital, Sweden University Hospital Bristol Ninewells Hospital, Dundee Royal Cornwall Hospital, Treliske St James's University Hospital , Leeds F is being used.reemantle Hospital Australia Kent & Canterbury Hospital, East Kent University Hospital Padua, Italy Derriford Hospital, Plymouth Gloucester Hospitals NHS F is being used./T Mater Clinic, South Brisbane, Australia The Royal London Barts Health NHS Trust Torbay Hospital South Devon Healthcare NHS F is being used./T New Cross Hospital, Wolverhampton Salford Royal Hospital, Manchester St Mark's Hospital, Harrow York Teaching Hospital John Radcliffe Hospital Oxford Kings College Hospital, London Watford General Hospital, West Herts Aintree University Hospitals NHS Trust Airedale General Hospital, West Yorkshire Mid Yorkshire NHS Trust Norfolk & Norwich Hospital Poole Hospital NHS F is being used./Trust St George's, Tooting, London University Hospital of North Staffordshire Yorkhill Children's Hospital, Glasgow Paediatric Haifa, Israel Mount Sinai, Toronto, Canada Queen Elizabeth Hospital, Birmingham Royal Victoria Hospital, Newcastle Sussex County Hosp., Brighton University Hospital Calderdale Royal Hospital Chesterfield Royal Hospital F is being used.rimley Park Hospital, Surrey Llandough Hospital, Cardiff Musgrove Park Hospital, Taunton Royal Bournemouth General Hospital University College London Hospital University Hospital (Wythenshawe) South Manchester Birmingham Heartlands Hospital, Birmingham Chelsea & Westminster Hospital, London F is being used.reeman Hospital, Newcastle (RENAL) Kettering Hospital, Northampton King's Mill Hospital, Nottinghamshire NHS F is being used.orth Valley Royal Hospital, Larbert, Scotland Princess Alexandra Hospital, Essex Shrewsbury & Telford Hospital South Tyneside NHS F is being used.oundation Trust 53 52 35 26 24 24 23 22 20 18 18 17 16 15 15 13 13 12 11 11 11 11 11 10 10 10 10 9 9 9 8 8 8

8 8 8 8 8 7 7 7 7 7 6 6 6 6 6 6 6 6 5 5 5 5 5 5 5 5 5 Weston Area NHS Trust Hospital, Weston-S-Mare Aberdeen Royal Infirmary Basingstoke & North Hants Hospital Darlington Memorial & Bishop Auckland Hospital Great Ormond Street Hospital Paediatric Royal Blackburn Hospital East Lanc's South Africa, Groote Schuur Stoke Mandeville Hospital, Bucks The James Cook University Hospital, South Tees Warrington Hospital, Warrington & Halton Basildon Hospital Bradford Royal Infirmary Colchester General County Hospital Hereford Dudley Group of Hospitals Glasgow Royal Infirmary Nottingham Children's Hospital, NUH-Paediatric Royal Liverpool & Broadgreen Scunthorpe General Hospital University Hospital of North Tees West Middlesex University Hospital Alder Hey Childrens Hospital Cross House Hospital, Ayrshire & Arran, Scotland Dorset County Hospital Harrogate & District NHS F is being used.oundation Trust Kiel, Germany Luton & Dunstable Hospital Mater Dei Hospital, Malta Milton Keynes Hospital, Buckinghamshire Queen Alexandra Hospital, Portsmouth Regional Hospital Viborg, Denmark Royal Hallamshire Hospital, Sheffield Sandwell Hospital Birmingham Sheffield Children's Hospital Paediatric University Hospital of Ioannina, Greece Worthing Hospital, West Sussex Epsom & St Hellier Hospital Ipswich Hospital Leeds General Infirmary Hospital Paediatric Leicester General Hospital Paediatric Lewisham University Hospital Manchester Royal Infirmary North Cumbria Hospital Royal F is being used.ree Hospital, Hampstead Royal Hampshire County Hospital Royal United Hospital, Bath Sandwell Hospital Birmingham Shaare Zedek Medical Centre, Israel Southmead Hospital, North Bristol St James's University Hospital, Leeds & Nott's Children's University Hospital of Wales, Cardiff Worcester Royal Infirmary Total from UK sites Total from International sites PRED4 GRAND TOTAL RECRUITED 5 4 4 4 4 4 4 4 4 4 3 3 3 3 3 3 3 3 3 3 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 744 105 849

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